Simultaneous whole-body PET/MRI with integrated multiparametric MRI for primary staging of high-risk prostate cancer
World Journal of Urology Jan 10, 2020
Kaufmann S, Kruck S, Gatidis S, et al. - Researchers conducted this prospective study, high-risk prostate cancer (hrPC) people scheduled to radical prostatectomy (RPx) with extended lymphadenectomy (eLND) were staged with wbPET/MRI and either 68Ga-PSMA-11 or 11C-choline involved simultaneous multiparametric MRI (mpMRI) in order to contrast the diagnostic efficiency for T-staging of PET-blinded reading (PBR) and whole-body positron emission tomography/magnetic resonance imaging (wbPET/MRI)[promising diagnostic tool of recurrent prostate cancer (PC)]. In total of 34 people who undergone wbPET/MRI of 68Ga-PSMA-11 (n = 17) or 11C-choline (n = 17). Of which 24 individuals were fitted with the inclusion standards of localized disease ± nodal disease on the basis of imaging outcomes underwent RPx and eLND, whereas 10 people were eliminated from the analysis due to metastatic disease. It was found that in direct contrast with final pathology, MpMRI was the primary modality for T-staging in hrPC as PET underestimated T-stage. Moreover, this chosen study, cohort MRI reveals no inferiority than wbPET/MRI considering N-staging.
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