Zhu L, et al. – In this study, researchers primarily assessed the expression, distribution, and prognostic values of aquaporins (AQPs) in breast cancer patients by using the Oncomine database, Breast cancer Gene-Expression Miner v4.1, Kaplan–Meier Plotter, and cBioPortal. They noted upregulation of mRNA expression levels of AQP8, AQP9, and AQP10, and downregulation of mRNA expression levels of AQP3, AQP4, AQP5, and AQP7 in breast cancer. A high Scarff–Bloom–Richardson grade was noted in relation to lower mRNA levels of AQP1 in the clinical database, but the opposite trend was reported for AQP9. In further survival analyses, better relapse-free survival was observed with high mRNA expression levels of AQP0, AQP1, AQP2, AQP4, AQP6, AQP8, AQP10, and AQP11. Conversely, in breast cancer patients, worse RFS was noted in relation to AQP3 and AQP9, which might be potential targets in future chemotherapy.