Fan YL, et al. - Researchers investigated whether hypertension and high homocysteine (HHcy) interact to increase neurological severity in Chinese first-ever ischemic stroke patients. Hypertension and tHcy were shown to be independently related to neurological severity, with total homocysteine (tHcy) identified as a significant predictor of neurological severity in receiver-operating characteristic analysis. Compared to patients without each condition, researchers also found a more than multiplicative interaction between hypertension and Hhcy on neurological severity, while on an additive scale, moderate/severe neurological severity in 76.4% of patients could be attributed to this interaction.