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Significant decrease in the prevalence of hepatitis C infection after the introduction of direct acting antivirals

Journal of Gastroenterology and Hepatology Jan 23, 2020

Rodríguez-Tajes S, Domínguez Á, Carrión JA, et al. - In this community-based study involving 3,328 people, researchers sought to update the prevalence of hepatitis C and B infection in Catalonia, utilizing point-of-care tests to investigate the risk factors related and to implement a linkage-to-care circuit. Point-of-care tests for anti-HCV and HBV-HBsAg and a questionnaire for risk factor assessment have been conducted. The overall prevalence of anti-HCV and HBsAg were lower than expected, 1.02% and 0.52%, respectively. Drug use, blood transfusion, a relative with HCV and diabetes were the associated risk factors. HCV infection prevalence was lower than previously reported, showing a strong impact of direct acting antivirals therapy in the last years. HBV infection in Catalonia is mainly related to the migrant population due to hepatitis B universal vaccination. Linkage-to-care in patients with hepatitis B has been challenging and warrants further efforts.
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