Du Q, et al. - Given that owing to their relatively high specificity and stability autoantibodies tumor-associated antigens (TAAs) could be a valuable tool for the diagnosis or early detection of cancer, researchers detected the level of tumor-associated autoantibodies (AAbs) in lung cancer. They also evaluated the diagnostic potential of autoantibodies in screening strategy for early stage lung cancer. Against a panel of seven TAAs (p53, PGP9.5, SOX2, GAGE7, GBU4-5, CAGE and MAGEA1), levels of tumor-associated AAbs were measured. Persons without any nodules in the lung after chest MDCT scan were included as controls. With sensitivity of 56.53% and specificity of 91.60%, differentiation of malignant lesions from benign lesions and control people was allowed by AAbs panel. When combined with CT, the specificity could be further increased to 95.80%. Overall, this assay corroborated the utility of AAbs panel as a diagnostic tool combined with CT scan.