Park JY, et al. - This analysis was formulated in order to examine the clinicopathological significance of microcystic, elongated, and fragmented (MELF)-like features, with the intention of determining if they represented regenerative or truly neoplastic conditions in pancreatic intraductal papillary mucinous neoplasms (IPMNs). A possible correlation was noted between MELF-like features in some IPMNs having high-grade dysplasia with stromal invasion. In the presence of MELF-like features in IPMNs, pathologists were recommended to cautiously assess the outcomes of microscopic examinations to identify the invasive components. It was reported that immunohistochemical staining for DPC4 and p53 could aid in clarifying its clinicopathological significance.