Higuchi T, et al. - Given the established usefulness of ¹⁸F-fluorodeoxyglucose-positron emission tomography/computed tomography for evaluating the treatment efficacy of breast cancers, researchers sought the predictive values of parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in 199 breast cancers treated with primary systemic chemotherapy (PSC) followed by operation. Sixty-four breast cancers showed a pathological complete response (pCR). pCR was noted in significant correlation with low levels of MTV at baseline and a high reduction of SUVmean after PSC. Hence, these metabolic parameters thus supported to have predictive value for the treatment efficacy of breast cancers.