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Significance of examined lymph nodes number and metastatic lymph nodes ratio in overall survival and adjuvant treatment decision in resected laryngeal carcinoma

Cancer Medicine Mar 09, 2020

Zhu X, et al. - In this large SEER-based cohort study, researchers examined the existing parameters of lymph node status that could anticipate survival outcomes and the prognostic value of adjuvant treatment in resected laryngeal carcinoma. Population-based data from the US Surveillance, Epidemiology, and End Results (SEER-18) Program on patients after laryngectomy and lymphadenectomy (2004-2015) have been studied. Using the X-tile program, the optimal cut-off values for examined lymph nodes number and metastatic lymph nodes ratio were determined. In total, 2,122 individuals with resected laryngeal cancer were analyzed. In this study, a new survival-predicting model was developed which was superior in evaluating the survival outcomes of patients with resected laryngeal cancer. Notably, this model has also been able to assist patients and doctors in the decision making of adjuvant therapy.
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