von Stuckrad SL, Klotsche J, Biesen R, et al. - Researchers conducted the study for analyzing the validity of membrane-bound SIGLEC1 (CD169) as a sensitive biomarker for monitoring disease activity in pediatric systemic lupus erythematosus (SLE). Twenty-seven children and adolescents with SLE were followed for a mean of 13.5 months. Connections between biomarkers and the clinical course were examined by regression analysis. According to findings, SIGLEC1 expression on monocytes is a sensitive biomarker for adjusting disease activity in childhood SLE and is a promising and easily accessible method for disease monitoring.