Shorter and longer courses of antibiotics for common infections and the association with reductions of infection-related complications including hospital admissions
Clinical Infectious Diseases Feb 27, 2021
Palin V, Welfare W, Ashcroft DM, et al. - Completion of the treatment course has been emphasized in view of the fact that antimicrobial resistance is a serious global health concern. Researchers here examined the duration of prescribed antibiotics along with their effectiveness and linked risk of infection-related complications. Clinical Practice Research Datalink yielded data of 4 million acute infection episodes prescribed an antibiotic in primary care between January 2014 – June 2014, England. Over the study period, there was an increase in the duration of antibiotic courses (5.2-19.1%); 6-7 days were most common (66.9%). Finding revealed that shorter and longer antibiotic courses were equally effective. However, most infection-related hospitalizations were reported among those with prescriptions of 8-15 days (0.21%), along with greater risk of infection-related complications compared with patients that received a short prescription. Based on findings, they recommending shorter courses of antibiotics for acute infections in stewardship programs.
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