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Short-term teriparatide and recombinant human bone morphogenetic protein-2 for regenerative approach to medication-related osteonecrosis of the jaws: A preliminary study

Journal of Bone and Mineral Research Aug 29, 2017

Jung J, et al. – A preliminary study was conducted to analyze whether adjunct teriparatide administration and local application of recombinant human bone morphogenetic protein–2 (rhBMP–2) is beneficial for the regeneration of jaw bone in patient with medication related osteonecrosis of the jaw (MRONJ). They found significantly greater amount of bone formation in the group PTH+BMP than in the BMP and control groups. It was also noted that local application of rhBMP–2 also had a beneficial impact on bone regeneration but was not significant than control. As per the data, administration of teriparatide with rhBMP–2 in medication related osteonecrosis of the jaw patients may maximize the regeneration of bone.
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