Potter S, et al. - Whether immediate implant-based breast reconstruction performed with and without mesh has reliable short-term safety was investigated to assess the feasibility of undertaking a future randomized clinical trial comparing different breast reconstruction techniques. Researchers analyzed 3-month outcome data available for 2,081 (99%) patients, among 2,108 patients aged 16 years or older had 2,655 mastectomies with immediate implant-based breast reconstruction at 81 participating breast and plastic surgical units in the UK between February 1, 2014 and June 30, 2016. A total of 1,376 (65%) patients had reconstruction with biological (1,133 [54%]) or synthetic (243 [12%]) mesh, 181 (9%) had non-mesh submuscular or subfascial implants, 440 (21%) had dermal sling implants, 42 (2%) had pre-pectoral implants, and 79 (4%) had other or a combination of implants. Findings revealed implant loss in 182 patients, need for hospital re-admission in 372 and return to theatre in 370 due to complications within 3 months of their initial surgery. Treatment for an infection was seen in 522 patients. These rates were higher than those in the National Quality Standards (<5% for re-operation, re-admission, and implant loss, and <10% for infection).