Mammoto T, Fujie K, Taguchi N, et al. - Researchers assumed that early postoperative administration of celecoxib would decrease pain scores and improve sleep quality and active range of motion after total knee arthroplasty (TKA) under general anesthesia. After TKA, individuals in the celecoxib group received 400 mg of celecoxib 2 hours, followed 6 hours later by 200 mg of celecoxib. After surgery, individuals in the control group received 400 mg of celecoxib the second day. After TKA, early administration of celecoxib was correlated with significantly decreased early visual analog scale pain scores and improved sleep quality and active knee flexion angles. Therefore, after TKA, the early administration of celecoxib under general anesthesia may decrease pain and improve sleep quality and functional recovery.