Bahrami S, Steen NE, Shadrin A, et al. - To find out the extent of the overlap between the genetic architectures of major psychiatric disorders (MPDs) and BMI and identify genetic loci shared between them, researchers analyzed independent genome-wide association study data on individuals with schizophrenia (SCZ) (n = 82,315), bipolar disorder (BIP) (n = 51,710), major depression (MD) (n = 480,359), and BMI (n = 795,640) by using a conditional false discovery rate statistical framework. They excluded the UK Biobank cohort (n = 29,740) from the MD data set to avoid sample overlap. They obtained data between August 2017 and May 2018, and analysis began in July 2018. They detected extensive polygenic overlap between BMI and SCZ, BIP, and MD, and distinguished 111 shared genetic loci, involving novel functional mechanisms. These results distinguish common genetic loci BMI and major psychiatric disorders and show mixed association directions with mainly opposite correlations in schizophrenia and BMI.