Duncan DT, et al. - Experts evaluated if sexual orientation (ie, sexual identity and sexual attraction) is a risk factor for prescription opioid misuse and use disorder among a nationally representative sample of adults in the US. They used the data from adult participants (ages ≥18 years) in the 2015 National Survey on Drug Use and Health. They found the sexual orientation disparities in opioid misuse and use disorder in a nationally representative sample of US adults. Bisexual individuals were at 1.53 and 1.66 higher odds of reporting past-year and past-month misuse, respectively, compared with those identifying as heterosexual; as seen in multivariable analyses. The stratified analysis suggested these correlations to be limited to females.