Mefford MT, Li BH, Qian L, et al. - Given a decline in incident acute myocardial infarction (AMI) rates in the US in recent decades but existing differences by gender, researchers assessed temporal trends in incident AMI among women and men, using an integrated healthcare delivery system. From Kaiser Permanente Southern California, they selected hospitalized AMI among members ≥ 35 years of age. This analysis included 45,331 AMI hospitalizations. From 2000 to 2014, a reduction in age- and gender-standardized incidence rates of AMI was seen from 322.4 to 174.6, respectively, depicting an average annual percent change (AAPC) of –4.4% and a period percent change of –46.6%. In women, the AAPC for AMI was reported to be –4.6% between 2000 and 2009, and reduced to –2.3% between 2010 and 2014. During the study span, stable AAPC for AMI was reported in men. Overall, findings revealed a decline in hospitalized AMI incidence between 2000 and 2014, however, women vs men demonstrated slowed declines in AMI in recent years. These gender-based AMI differences may be decreased by ascertaining unmet care needs in women.