Alraies MC, Kaki A, Kajy M, et al. - Among patients who underwent high-risk percutaneous coronary intervention (PCI) with mechanical circulatory support (MCS), researchers investigated in-hospital and short-term outcome differences between males and females. They selected 1,053 high-risk patients who had PCI with MCS using Impella 2.5 or Impella CP, from the cVAD Registry. They excluded those with cardiogenic shock. A median follow-up of 81.5 days was performed in 792 (75.21%) males and 261 (24.79%) females. The likelihood of being African American, older, have a higher prevalence of diabetes, renal insufficiency, and peripheral vascular disease, was more in females. A higher mean STS score and lower cardiac output on presentation were also noted in women. With regard to in-hospital mortality, stroke, MI or requirement for recurrent revascularization, no difference was observed between women and males. Findings revealed similar outcomes between female patients undergoing high PCI vs males, although older age and more comorbidities were noted in female patients.