Kaul P, et al. - Among elderly (≥ 65 years) male (n = 2691) and female (n = 2305) patients with acute coronary syndromes (ACS), researchers assessed the prevalence of self-reported frailty and its relation to all-cause mortality. The participants were included in the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes (TRILOGY ACS) trial. Screening was performed in these subjects by using the Fried Frailty Index. Findings revealed men and women with ACS had similar self-reported frailty. Only in men, increases in frailty with aging were evident. Frailty offered more prognostic information in men. Elderly patients with ACS, especially men, at high-risk of mortality, could be detected by patient-reported frailty.