Ross KR, Gupta R, DeBoer MD, et al. - Via this prospective inquiry, researchers investigated if well-characterized children with severe asthma outgrow severe asthma during adolescence. They administered detailed questionnaires, allergy testing and lung function testing to evaluate children with asthma at baseline. These children were re-evaluated annually for three years. In longitudinal analysis of this well-characterized cohort, they found that among children with severe asthma, half were no longer severe following three years; a stepwise drop in the proportion meeting severe asthma criteria was noted. The observed reduction in asthma severity between males and females was equal. The resolution was predicted by peripheral eosinophilia.