Chen H, et al. - Researchers sought to determine hub genes linked with cutaneous squamous cell carcinoma (cSCC) and actinic keratosis (AK). They utilized three datasets GSE45216, GSE98774, and GSE108008, and integrated samples from the GSE45216 and GSE98774 datasets into the new dataset GSE45216–98774. Modules most relevant to cSCC and AK were discovered. GATM, ARHGEF26, PTHLH, MMP1, POU2F3, MMP10 and GATA3 were the seven hub genes of cSCC that were identified and validated. No validated hub genes for AK were found. There was a significant association of each hub gene with the survival of several malignancy types. A significant link with melanoma survival was shown only by GATA3. In this study, seven hub genes were unveiled by applying weighted gene co-expression network analysis. These genes were shown to have crucial roles in cSCC tumorigenesis. These observations offer new insights that assist in explaining cSCC pathogenesis. These hub genes may serve as biomarkers or treatment targets for accurate diagnosis as well as management of cSCC in the future.