Then C, Then HL, Lechner A, et al. - Researchers performed this population-based KORA F4 study, to examine the link of serum uromodulin with cardiovascular morbidity and cardiovascular as well as total mortality, stratified by gender. Among 1,079 participants (age 62–81 years), baseline serum uromodulin was measured. A median follow-up of 8.6 years was performed. Findings revealed a significant inverse link of serum uromodulin with total mortality and cardiovascular mortality in males, but not in females following adjustment for age, BMI, diabetes and eGFR. Also, a significant inverse link was identified between serum uromodulin and incident stroke in males, but not in females following multivariable adjustment. The link between serum uromodulin and incident myocardial infarction was not only attenuated but also lost significance following multivariable adjustment in both genders. As per the findings, among men from the general community aged 62 years or older, serum uromodulin was identified as an independent biomarker for total and cardiovascular mortality.