Deng N, Mallepally N, Peng FB, et al. - A systematic review was performed to evaluate the association between serum testosterone and laboratory, anthropometric, and clinical outcomes in observational and interventional studies in cirrhosis. Researchers carried out searches of PubMed and EMBASE from inception through August 27, 2020. The Newcastle Ottawa Scale for non‐interventional studies and the Cochrane Risk of Bias for interventional studies were used to evaluate methodological quality. For this analysis, 15 met inclusion criteria with 6 observational studies of 1,267 patients and 9 interventional studies of 580 patients, out of 3,569 articles. The data exhibited that in cirrhosis patients, low serum testosterone is correlated with increased morbidity and mortality. Intermediate endpoints were improved by testosterone supplementation, but there was no conclusive data on clinical outcomes. It has been considered that in cirrhosis, testosterone supplementation may be a promising strategy to improve frailty and decrease significant clinical complications.