Yim JY, et al. - Researchers in US adults participating in the 2011-2012 National Health and Nutrition Examination Survey examined the link between serum total testosterone and non-alcoholic fatty liver disease. They excluded subjects with significant consumption of alcohol and those with viral hepatitis. Of the 4758 subjects (49.4% men), the prevalence of suspected non-alcoholic fatty liver disease in men and women was inversely correlated with sex-specific testosterone quartiles. The multivariate model disclosed a connection between low total testosterone levels with progressively higher odds of suspected non-alcoholic fatty liver disease in men after adjusting for age, obesity and other metabolic risk factors. Low total testosterone levels, independent of known risk factors, were related to suspected non-alcoholic fatty liver disease in men and postmenopausal women.