Hasslacher J, Rass V, Beer R, et al. - Researchers examined the value of serum tau protein as a biomarker for poor neurological outcome over an extended observation period in patients following successful cardiopulmonary resuscitation (CPR) managed with mild therapeutic hypothermia (MTH) or normothermia. A prospective observational study including 132 patients after successful CPR was assessed in this retrospective analysis. Treatment with MTH was provided to 43% of the patients. , serial serum tau levels (pg/ml) showed a peak (159 (IQR 27–625). Between 72–96 h after CPR, serum tau showed the highest values and the best prognostic discrimination of poor neurological outcome. In patients with hypoxic encephalopathy, the prolonged rise may infer ongoing axonal damage.