Banales JM, et al. - Researchers ascertained if serum metabolome can distinguish between intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC) and provide useful biomarkers for the diagnosis of iCCA and HCC. Since primary sclerosing cholangitis (PSC) is a risk factor for CCA, PSC and CCA serum metabolic profiles were also compared. Differential profiles were found in the analysis of lipid and amino acid levels in the serum of patients with iCCA, HCC, PSC and healthy individuals. Findings suggested that specific changes in serum concentrations of certain metabolites were helpful in distinguishing iCCA from HCC or PSC and could help diagnose these diseases at an early stage.