Banales JM, et al. - This study was undertaken to determine if serum metabolome can distinguish of intrahepatic cholangiocarcinoma (iCCA) from hepatocellular carcinoma (HCC) and provide useful biomarkers in the diagnosis of iCCA and HCC. Researchers analyzed the levels of lipids and amino acids in the serum of patients with iCCA, HCC, and primary sclerosing cholangitis (PSC), since PSC is a risk factor for CCA), as well as healthy individuals. They found that the analysis of the levels of lipids and amino acids in the serum of these patients displayed differential profiles. Results of this study suggested that specific changes in serum concentrations of certain metabolites were helpful in distinguishing iCCA from HCC or PSC and could help diagnose these diseases early.