Semba RD, et al. - Using a lipidomic approach, researchers examined the association between serum lipids and age-related macular degeneration (AMD) in older adults. From a population-based sample of participants in the Age Gene/Environment Susceptibility-Reykjavik Study, 240 adults (aged ≥ 66 years)—one-third each having geographic atrophy, neovascular AMD, or no signs of AMD—were selected. Of the 177 serum lipid species measured, no significant differences in serum lipids were observed between controls and those with geographic atrophy or neovascular AMD. Serum lysophosphatidylcholine 18:0 was higher than geographic atrophy in adults with neovascular AMD. Overall, no association of serum lipids with late AMD was found in this case-control study.