Shen H, et al. - Lipid profiles have been linked with an increased risk of stroke and depression, so researchers assessed the possible connection between serum lipid profiles and post-stroke depression (PSD), a common psychiatric complication of stroke, in 373 patients with acute ischemic stroke. Serum lipid profiles were measured within 24 hours of admission, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), total cholesterol (TC), apolipoprotein A1 (Apo A1) and apolipoprotein B (Apo B). Depression symptoms were evaluated at one-month by the 17-item Hamilton Depression Scale (HAMD-17), and PSD diagnosis was indicated by HAMD scores ≥7. At one month, PSD was diagnosed in 114 (30.6%) patients. According to findings, PSD is associated with decreased HDL-C levels and elevated LDL/HDL ratio levels. HDL-C and the ratio LDL/HDL can be independent PSD predictors. No differences were seen in TGs, TC, Apo A1 or Apo B.