Liu K, Jing P, Liu Z, et al. - A high risk of osteoporosis-related hip fractures as well as of osteoporosis was evident in the presence of decreased serum levels of circulating irisin.

• This cross-section and case-control study included 430 postmenopausal women aged 50–90 years (215 with hip fractures and 215 age-matched cases without fracture).

• Lower mean serum levels of irisin were present in women with hip fractures vs normal control women.

• Irisin levels in third and fourth quartiles were related to hip fracture risk (the lowest quartile was reference), and risk of fracture decreased by 67% (hazard ratio [HR] = 0.33) and 84% (HR = 0.16).

• Irisin concentrations in third and fourth quartiles were also linked with osteoporosis risk, and fracture risk decreased by 55% (HR = 0.45) and 73% (HR = 0.27).