Moradi N, Fouani FZ, Vatannejad A, et al. - The results reveal a possible relationship between serum asprosin and the pathogenesis of coronary artery disease (CAD), in particular through insulin resistance and dyslipidemia.

• When compared to non-CAD individuals, serum asprosin was found to be higher in CAD patients (7.84 ± 2.08 vs 5.02 ± 1.29 μg/mL, p <  0.001).

• Similarly, there was a significant elevation in serum TNF-α, and IL-6 in the CAD group (p <  0.001).

• Nevertheless, when compared with non-CAD individuals, circulating adiponectin diminished in the CAD group (p < 0.001).

• The results exhibited that serum asprosin levels are directly associated with BMI, FBG, HOMA-IR, TG, and TC.

• Furthermore, logistic regression analyses demonstrated that asprosin levels were correlated with an elevated risk of developing CAD (odds ratio: 3.01, 95% CI: 2.16, 4.20 and p < 0.001), after adjusting for potential confounders (age, gender, and BMI).