Cheng CW, Fang WF, Tang KT, et al. - This study was intended to assess four groups of inflammatory cytokines, including interferons (IFNs), the tumor necrosis factor (TNF) superfamily, interleukin (IL)-related cytokines, and bone and extracellular matrix remodeling-related cytokines to ascertain their contributions in women with overt Graves' disease (GD). This cross-sectional study included 43 women with GD. Researchers evaluated 37 cytokines, thyroid-stimulating hormone (TSH), free thyroxine, and TSH receptor antibody (TSHRAb). They characterized GD patients with a low TSH level at the time of sample collection as having active GD. This study’s findings demonstrate that in women with full-blown GD, serum IFNs could be the most remarkable cytokines in modulating the disease severity and TSHRAb titers. Future molecular-based study to verify the actual role of IFNs in the disease progression of GD is required.