Shen J et al. -Circulating long non-coding RNAs (lncRNAs) are a new class of cancer biomarkers. However, their significance in predicting outcomes in glioblastoma patients is unclear.HOTAIR and GAS5 levels could serve as reciprocal prognostic predictors of survival and disease progression in patients with glioblastoma.

Methods

• The levels of six known oncogenic lncRNAs (CRNDE, GAS5, H19, HOTAIR, MALAT1, and TUG1) were measured in serum samples from 106 patients with primary glioblastomas.

Results

• High levels of HOTAIR were associated with an increased likelihood of death (aHR = 2.04), recurrence, and progression (aHR = 1.82).
• High levels of GAS5 were associated with a decreased likelihood of death (aHR = 0.44), recurrence, and progression (aHR = 0.46).