Wu L, et al. - In this prospective single center study with 105 sepsis patients, researchers focused on the utility of serum Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) for diagnosing sepsis-related encephalopathy (SAE), predicting prognosis and long-term quality of life with patients of sepsis. For diagnosis of SAE, the AUC yielded by GFAP and UCH-L1 were 0.824 and 0.812 respectively, with optimal cut-off values 0.532 ng/ml and 7.72 ng/ml respectively. GFAP and UCH-L1 allowed differentiation of patients with survivors from non-survivors with optimal cut-off values of 0.536 ng/ml and 8.06 ng/ml with an area under the curve of 0.773 and 0.746, respectively. Overall, early elevation of serum levels of GFAP and UCH-L1 was seen. Findings revealed the association of serum levels of GFAP and UCH-L1 with sepsis-associated encephalopathy, poor prognosis and quality of life.