Yadav P, et al. - Researchers studied the associations between renal function, demographic, and disease characteristics, including serum free light chain (FLC) levels at diagnosis, in 1,595 newly diagnosed multiple myeloma (MM) patients. They used data from the Medical Research Council Myeloma IX trial (a multicenter, randomized, open-label, phase 3 and factorial-design trial). Findings demonstrated a strong link between higher serum FLC levels at diagnosis, regardless of the paraprotein type, and the severity of renal impairment. An increased risk of severe RI was observed in patients presenting with serum FLC levels above 800 mg/L at diagnosis.