Zylla S, et al. – The target of this paper is to evaluate the correlation of serum chemerin with renal function in a general population with special regard to possible interactions between chemerin and metabolic phenotypes. The outcomes illustrate a strong inverse correlation between serum chemerin levels and renal function. This correlation might be explained by metabolic syndrome (MetS)–related phenotypes, which lead to renal damage and are correlated with increased chemerin levels, and/or an impaired renal elimination of chemerin by diseased kidneys.