Serum cardiac troponin elevation predicts mortality in patients with pulmonary hypertension: A meta-analysis of eight cohort studies
The Clinical Respiratory Journal Feb 28, 2019
Xu SL, et al. - Researchers assessed if there is a link between serum cardiac troponin (cTn) and mortality in pulmonary hypertension (PH) patients. They identified relevant studies from inception to October 25, 2017, in PubMed and EMBASE and by consulting reference lists of the retrieved articles. Based on the type of troponin (cTnT vs cTnI), region (Europe vs America) and follow-up length (≤3 years vs >3 years), stratification of studies was carried out. Overall, 8 studies with 739 patients were used. The reported range of cardiac troponin elevation was from 14.3% to 94.5%. Different methods were used in different studies to detect the expression cTnT or cTnI, but the cTn-positive group vs the cTn-negative group still exhibited a higher mortality. Increased risk of mortality in PH patients was independently predicted by serum cTn elevation.
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