Hurnakova J, et al. - Authors evaluated the levels of serum calprotectin in rheumatoid arthritis (RA) patients with clinically active disease and with normal/low C-reactive protein (CRP). They assessed the discriminatory capacity of calprotectin to identify clinically active patients in spite of normal/low CRP using receiver operating curves (ROC). Calprotectin levels were significantly higher in patients with moderate to high disease activity vs those patients who had normal/low CRP and were in remission or showed low disease activity, which differed from those in healthy subjects. In RA patients where CRP fails to reflect inflammatory activity, calprotectin could do so.