Yang G, Sun T, Han YY, et al. - Using multivariable logistic or linear regression, researchers assessed current wheeze, current asthma, and lung function in US adults in correlation with serum levels of cadmium and lead. They considered a cross-sectional analysis including 13,888 adults aged 20 to 79 years in 2007-2012 NHANES. In all participants and in never/former smokers, they observed a significant link of serum cadmium with lower (forced expiratory volume in 1 second) FEV₁% predicted, FEV₁/(forced vital capacity) FVC% predicted, and fractional exhaled nitric oxide. In all participants, a significant link of serum lead with lower FEV₁/FVC% predicted was found, with similar results in never/former smokers and in current smokers. In this study, an increased risk of wheeze and asthma was observed in relation to exposure to cadmium in US adults who currently smoke. Also, negative influences of exposure to cadmium or lead on lung function were suggested in nonsmoking US adults.