Bai X, Sun M, He Y, et al. - This study intended to assess serum CA72-4 expression in gout patients and verified the hypothesis that CA72-4 is a predictor of future flares in a prospective gout cohort. A cross-sectional study was performed in individuals with gouty arthritis, asymptomatic hyperuricaemia, four major arthritis types (OA, RA, SpA, septic arthritis) and healthy controls to profile CA72-4 expression. Compared with hyperuricaemia patients, healthy subjects and other arthritis patients, CA72-4 was highly expressed in individuals with gouty arthritis. They observed the gout flares, CA72-4 levels and other gout-related clinical variables at 1, 3 and 6 months during a 6-month follow-up. In gout individuals, CA72-4 levels were upregulated who experienced frequent flares and CA72-4 was a beneficial biomarker to predict future flares.