Karppinen J, Koivisto K, Ketola J, et al. - This study was undertaken to investigate the existence of serum biomarkers in chronic low back pain (CLBP) patients with Modic change (MC). Researchers evaluated age- and gender-matched CLBP patients with confirmed MC on lumbar MRI (n = 40) and pain-free controls (n = 40). They categorized MC into M1, predominating M1, predominating M2, and M2. They further estimated MC volumes. They evaluated fasting blood samples for inflammatory mediators, signalling molecules, growth factors, and bone turnover markers. They further assessed serum concentrations of 46 biomarkers. This is the first research to evaluate the blood serum biomarker profile in individuals with CLBP with MC. According to the findings, several biomarkers were suppressed, while two markers (IL-1sRII and hepatocyte growth factor) were increased among MC patients, irrespective of MC type or size, with CLBP in comparison with asymptomatic controls.