Allegretti AS, et al. - Investigators assessed Angiopoietin-2 to predict clinical outcomes considering the prominence of vascular destabilization in decompensated cirrhosis. For this examination, serum Angiopoietin-2 was measured serially in a prospective cohort of hospitalized subjects with decompensated cirrhosis and acute kidney injury. They examined clinical characteristics and outcomes over a 90-day period and analyzed according to Angiopoietin-2 levels. Findings suggested an association of increased Angiopoietin-2 levels with increased mortality, higher Acute Kidney Injury Network stage, and need for renal replacement therapy. In a cohort of decompensated cirrhotic patients with acute kidney injury, Angiopoietin-2 was related to mortality and other clinically relevant outcomes.