Mir F, Pearce RE, Baig-Ansari N, et al. - Simplified antibiotics are recommended by WHO for young infants with sepsis in countries where hospitalization is not feasible, researchers here investigated pharmacokinetics, drug disposition and interpopulation variability of oral amoxicillin in this demographic. They studied young infants with signs of sepsis that were enrolled in an oral amoxicillin/intramuscular gentamicin treatment arm of a sepsis trial in Karachi, Pakistan. One hundred twenty nine samples obtained from 60 young infants were assessed for amoxicillin concentrations. Positive blood cultures with predominant Gram-positive organisms were reported in six of 44 infants. The analysis was performed on 44 infants contributing blood at ≥ 2 of 3 specified timepoints. Per findings, sera of young infants had amoxicillin concentrations exceeding the susceptibility breakpoint for > 50% of a 12-hour dosing interval following oral administration at 75–100 mg/kg/day daily divided doses.