Komorita Y, et al. - In this prospective study, analysts intended to evaluate the association between serum adiponectin and fracture risk in individuals with type 2 diabetes. The data showed that higher serum adiponectin levels were significantly correlated with an increased risk of fractures at any site and with an increased risk of major osteoporotic fractures in individuals with type 2 diabetes, including postmenopausal women.

Methods

• Researchers carried out a multicentre prospective study to evaluate the influence of modern treatments on the prognoses of patients with diabetes mellitus.
• For this study, they followed 4869 participants with type 2 diabetes (mean age, 65 years), enrolling 1951 postmenopausal women (defined as self-reported amenorrhea for >1 year) and 2754 men, for a median of 5.3 years.
• Fractures at any site and major osteoporotic fractures (MOFs) were considered as preliminary endpoints.

Results

• Fractures at any site occurred in 682 participants, while MOFs occurred in 277 participants during the follow-up period.
• The obtained data indicates that age-adjusted HRs (95% CIs) of any fracture and MOFs for 1 SD increment in loge-transformed serum adiponectin were 1.27 (1.15, 1.40) and 1.35 (1.17, 1.55) in postmenopausal women and 1.22 (1.08, 1.38) and 1.40 (1.15, 1.71) in men, respectively.
• They exhibited evidence that HRs (95% CIs) of MOFs for hyperadiponectinaemia (≥ 20 μg/ml) were 1.72 (1.19, 2.50) in postmenopausal women and 2.19 (1.23, 3.90) in men.
• Evidence showed that the per cent attributable risk of hyperadiponectinaemia for MOFs was as high as being age ≥70 years or female sex.