Sanz B, et al. - Among 112 long-term nursing home residents (aged 84.9 ± 6.7 years), researchers examined the link between adiponectin serum levels and frailty-related parameters. Participants were examined for their serum adiponectin levels in combination with frailty-related parameters (ie, body composition, physical fitness, cognitive function, psychological parameters, and quality of life). Lower body weight, body mass index, body fat mass, fat mass/height², lean mass, lean mass/height,² and smaller waist and hip circumferences were reported in relation to higher serum adiponectin levels in women. In men, an inverse association of better cognitive function with adiponectin was observed. In women, a higher concentration of adiponectin was associated with decreased anxiety. In this study population, there was evidence of an association of adiponectin with body composition, cognitive function, and anxiety, with differential links by sex.