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Serum 25-hydroxyvitamin D and subsequent cancer incidence and mortality: A population-based retrospective cohort study

Mayo Clinic Proceedings Aug 08, 2021

Johnson CR, Dudenkov DV, Mara KC, et al. - Elevated risk for incident nonskin cancer and cancer-related mortality was present in relation to low 25-hydroxyvitamin D (25[OH]D) levels.

  • Of 8,700 persons without cancer history and with mean ± SD age of 51.5±16.4 years, 761 suffered from cancer during follow-up.

  • Post-adjustment, a greater nonskin cancer incidence was noted in relation to 25(OH)D values less than 12 ng/mL, vs 25(OH)D values of 20 to 50 ng/mL (reference group).

  • Increased cancer mortality was associated with 25(OH)D levels less than 12 ng/mL and 12 to 19 ng/mL, vs the reference group.

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