Fann JR, et al. - This randomized controlled trial aimed to assess the efficacy and tolerability of sertraline for major depressive disorder (MDD) within 1 year of sustaining a traumatic brain injury (TBI). For MDD, sertraline monotherapy was not superior to placebo in people with post–acute complicated mild to severe TBI. Further research was needed on the effectiveness of interventions that also addressed the significant psychosocial needs of this population.