Kwon YJ, et al. - Using a community-based prospective cohort study, researchers explored the connection of polymorphisms of serotonin, or 5-hydroxytryptamine (5-HT), related genes with type 2 diabetes in Korean adults. This study was conducted on 8840 participants. Logistic regression analysis was utilized to assess the connection of 3402 single nucleotide polymorphisms (SNPs) in serotonin related genes with type 2 diabetes after adjusting for baseline age, sex, body mass index, drinking status, and smoking status. An association was found between rs1176744 in HTR3B and type 2 diabetes. In addition, polymorphisms in the downstream region of HTR3B can contribute to the development of type 2 diabetes. Results from the study suggested that the serotonin pathway plays a role in diabetes development.