Kilonzo SB, Gunda DW, Majinge DC, et al. - This study was carried out to calculate the prevalence, associated factors, and knowledge level of these conditions among people who use drugs attending a methadone clinic in Tanzania. Researchers recruited 253 People who were using drugs receiving Methadone therapy. They obtained clinical data from the medical records and face-to-face interviews were performed to ascertain the behavioral risk factors and respondents’ knowledge on viral hepatitis and HIV. Infection rates among people who use drugs are still high and the general knowledge on preventive measures is inadequate, despite the efforts to curb viral hepatitis and HIV infections through Methadone clinics.