Kwon OC, et al. - Among patients suffering from systemic lupus erythematosus, researchers assessed the rate of seroconversion to antinuclear-antibody negativity as well as its link with subsequent systemic lupus erythematosus flare risk. They studied the data for patients having systemic lupus erythematosus with positive antinuclear antibodies (titer ≥1 : 40) at diagnosis as well as at least one repeat antinuclear antibody examination. A conversion of positive antinuclear antibodies to a titer below the cut-off of 1 : 40 was defined as seroconversion to antinuclear antibody negativity. Findings revealed the occurrence of seroconversion to antinuclear antibody negativity in 9.7% of patients over 53.5 months. A lower future systemic lupus erythematosus flare risk was observed in relation to seroconversion to antinuclear antibody negativity.