Singh JA, et al. - Using a US National Inpatient Sample from 1998 to 2016, researchers analyzed the epidemiology of serious infections among patients hospitalized with gout. This study involved patients with gout hospitalized with a primary diagnosis of pneumonia, sepsis/bacteremia, urinary tract infection (UTI), skin and soft tissue infections (SSTIs), or opportunistic infections (OIs). A total of 1,140,085 such hospitalizations were reported. Older age, more cases with a Charlson–Deyo comorbidity index score ≥2 and fewer female or non-White people were observed in the group of patients with gout hospitalized with serious infections vs patients without gout. Relative to sepsis patients, significantly lower multivariable-adjusted odds of health care utilization and in-hospital mortality were observed for patients with UTI, SSTIs, and pneumonia, and lower non-home discharge or in-hospital mortality were noted in patients with OIs. Overall, gout patients were found to have an increasing rate of serious infections particularly sepsis and pneumonia. Thus, outcome improvement and burden attenuation can be ensured by developing effective interventions targeting factors related to health care utilization and mortality.